My research aims to understand how cellular metabolism controls epigenetic states and cell fate decisions. I am particularly interested in the interface between SAM metabolism, redox metabolism, and chromatin regulation.
Current focus
1) SAM metabolism & epigenetic regulation
2) Redox metabolism and cell fate decisions
3) MAT2B as a regulatory factor in differentiation and cancer biology
Methods
- Cell-based assays and molecular biology (gene perturbation, protein analysis, etc.)
- Transcriptomic / proteomic data analysis and integrative interpretation
- Pathway-level analyses and hypothesis-driven validation
Keywords
SAM, methionine cycle, redox, NADPH, chromatin, histone methylation, differentiation, cancer metabolism